Introduction
Lee B. Reichman, M.D., M.P.H.

Relevance of the Tuberculin Test in Low-Prevalence Countries
Kitty Lambregts, M.D., Ph.D, M.P.H.

Developing a Clinical Tuberculin Test:
Tuberculin Characteristics, Reactivity and Potency

Sheldon L. Morris, Ph.D.

Randomized Clinical Trials of Specificities of
Commercially Available Tuberculins

Elsa Villarino, M.D., M.P.H.

Administering and Reading Tuberculin Skin Tests;
Interpreting Repeated Tuberculin Skin Tests

Richard Menzies, M.D., M.Sc.

Tuberculin Sensitivity Produced by Mycobacteria
Other than the Mycobacterium Tuberculosis Complex

George Comstock, M.D., Dr.P.H.

Interferon-γ Release Assay for Detection
of Tuberculosis Infection

Alfred Lardizabal, M.D.

The Role of the Nurse in
Diagnosing Latent TB Infection

Karen Galanowsky, R.N., M.P.H.


Dedication to
George Comstock, M.D., Dr.P.H.


George Comstock, M.D., Dr.P.H. passed away on July 15, 2007 after a long illness. We were particularly gratified that even though quite ill, Dr. Comstock saw fit to bring his chapter, “Tuberculin Sensitivity Produced by Mycobacteria other than Mycobacterium tuberculosis Complex,” up to date for the second edition of this monograph.

Much of our knowledge about latent tuberculosis infection is directly due to Dr. Comstock’s work. His research and application of its results, has served as the basis of the diagnosis and management of this condition.

Dr. Comstock was a good friend and mentor to us all. It is with gratitude, appreciation, and respect that we dedicate this monograph to his memory.

Lee B. Reichman, M.D., M.P.H.


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